iProtein provides access to Eidogen-Sertanty's Target
Informatics Platform (TIP) - the world's first protein structure informatics system
and knowledgebase enabling structural interrogation of the druggable genome.
TIP amplifies the rapidly expanding body of experimental
protein structural information found in the Protein Data Bank (PDB) by generating high accuracy protein structural models
across sequences found in Swiss-Prot, RefSeq, Ensembl, IPI, etc. TIP leverages
protein structural information across family members and corresponding crystal
structure templates using an algorithm that has been validated in several top pharmaceutical
companies and academic research sites. As such, TIP contains the world’s largest
repository of protein structures and models.
The Target Informatics Platform's content includes high
resolution protein structures with reliably annotated small molecule binding
sites, including >200,000 chains and comparative models of human proteins,
covering every major drug target family including proteases, kinases,
phosphatases, phosphodiesterases, nuclear receptors, and GPCRs.
In addition to TIP's high quality structural annotation,
it is the only database of its kind that stores all similarity relationships
between every sequence, structure, and binding site, making it an incredibly
powerful system for structural and comparative proteomics.