News & Events
2007 Press Releases
Eidogen-Sertanty Releases TIP-Enterprise
San Diego, CA (August 15, 2007) - Eidogen-Sertanty, Inc., a computational drug discovery solutions provider, today announced the release of TIP-Enterprise, a behind-the-firewall version of its Target Informatics platform.
Strongly complementing Eidogen-Sertanty's online version of the Target Informatics Platform Knowledgebase (TIP) which is actively used by hundreds of researchers throughout several top pharmaceutical and biopharmaceutical organizations worldwide, TIP-Enterprise now offers a very powerful and scalable behind-the-firewall version of the system. TIP-Enterprise includes a large protein structure knowledgebase and a fully integrated suite of state-of-the-art algorithms, including sequence-to-structure homology modeling (StructFast), structure similarity calculation (StructSorter), binding-site identification (SiteSeeker), and site similarity calculation (SiteSorter). TIP-Enterprise can be deployed on a single server or distributed across multiple servers and compute clusters (See TIP-Enterprise sample deployment).
TIP-Enterprise facilitates rapid, large-scale comparative analysis between public domain structures found in the RCSB Protein Databank (PDB), homology model structures generated from public domain sequence repositories, and now highly sensitive proprietary protein structures and protein-ligand complexes found only within an organization.
Complete with a large database of structures, models, known-/probable- binding-sites, and pre-computed similarities among each, the TIP-Enterprise knowledgebase supports two industry standard relational database systems, Oracle and MySQL. With a well documented schema, TIP-Enterprise opens the door for easy database access and tight integration with in-house and other commercially available informatics systems.
"With the concomitant explosion of public-domain and proprietary co-crystal structural information, many of our clients have requested a behind-the-firewall version of TIP," said Steve Muskal, CEO of Eidogen-Sertanty. "In response to this demand, we worked very closely with several prominent pharmaceutical companies to specify and develop a behind-the-firewall, relational-database ready solution. With TIP-Enterprise's support of proprietary structure upload and processing, we now offer a solution which, among other things, provides must-have insight into potential off-target liabilities associated with our customer's proprietary drug molecules."
"TIP's unique capability of leveraging new data to continuously expand its knowledgebase paves the way for enterprises to fully realize the value from their investment in proprietary structural data." said Joe Danzer, Sr. VP of Product Development. "While working with some of our collaborators throughout the development of the TIP-Enterprise system, we have witnessed validation of TIP's value on several in-house projects. We are confident that TIP-Enterprise will open doors for new insights in the drug discovery process."
For more information, please visit the Target Informatics Platform Product Description page.
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About Eidogen-Sertanty, Inc.
Eidogen-Sertanty is a privately held company that is dedicated to helping scientists discover new medicines with innovative software technology and knowledgebases. To find out more about Eidogen-Sertanty please visit www.eidogen-sertanty.com.